![]() Forward-looking statements are not guarantees of future performance, are based on certain assumptions and are subject to various known and unknown risks and uncertainties, many of which are beyond the Company’s control, and cannot be predicted or quantified and consequently, actual results may differ materially from those expressed or implied by such forward-looking statements. This press release contains “forward-looking statements.” Such statements may be preceded by the words “intends,” “may,” “will,” “plans”,”expects,” “anticipates,” “projects,” “predicts,” “estimates,” “aims,” “believes,” “hopes,” “potential” or similar words. Food and Drug Administration at this time. MGuard ™ EPS and CGuard ™ EPS are CE Marked and are not approved for sale in the U.S. ![]() MGuard Prime™ is a Cobalt Chromium stent wrapped in MicroNet™. While offering superior performance relative to standard stents in STEMI patients, MGuard Prime™ requires no change in current physician practice – an important factor in time-critical settings. MGuard Prime ™ EPS, integrated with MicroNet™, is designed to trap and seal thrombus and ruptured plaque, preventing distal embolization. MicroNet™ is a bio-stable mesh woven from a single strand of 20 micron Polyethylene Terephthalate. The CGuard™ EPS is designed to prevent peri-procedural and late embolization by trapping potential emboli against the arterial wall while maintaining excellent perfusion to the external carotid artery and branch vessels. The proprietary CGuard ™ Embolic Prevention System (EPS) uses the same MicroNet™ ™ technology featured on the MGuard ™ and MGuard Prime ™ coronary Embolic Protection Systems. InspireMD’s common stock is quoted on the NYSE MKT under the ticker symbol NSPR. InspireMD intends to pursue applications of this MicroNet™ technology in coronary, carotid (CGuard TM), neurovascular, and peripheral artery procedures. InspireMD (seeks to utilize its proprietary MGuard™ with MicroNet™ TM technology to make its products the industry standard for embolic protection and to provide a superior solution to the key clinical issues of current stenting in patients with a high risk of distal embolization, no reflow and major adverse cardiac events. Foreign patent rights include 13 issued patents focused in Israel, Canada, and China, and 16 pending patent applications. To-date, the Company’s patent rights in the United States include 4 issued patents and 10 pending applications. The issuance of these two patents provides further support for these pending therapies and applications. InspireMD continues to maintain a focus on its intellectual property portfolio, expanding coverage for its proprietary MicroNet™ TM technology, CGuard TM Embolic Prevention System for the treatment of carotid artery disease, and MGuard TM for coronary applications, in addition to several pending applications directed to its neurovascular and peripheral vascular platforms. The Optimized Drug Stent Assembly patent covers a stent assembly with the Company’s proprietary MicroNet™ TM technology that elutes a drug. The In Vivo Filter Assembly patent covers an assembly for filtering debris flow in a blood vessel. ![]() 9,132,003 entitled “Optimized Drug Eluting Stent Assembly.” 9,132,261 entitled “In Vivo Filter Assembly” and U.S. (NYSE MKT: NSPR) (“InspireMD” or the “Company”) a leader in embolic prevention systems (EPS), neurovascular devices and thrombus management technologies, announced today that the United States Patent & Trademark Office has issued two new patents to the Company on September 15 th, U.S. InspireMD Announces the Issuance of Two United States PatentsĬontinued Focus on Intellectual Property Results in Continued Portfolio ExpansionīOSTON, MA – Septem– InspireMD, Inc. ![]()
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![]() ![]() The French barber surgeon Ambroise Paré also described syndactyly in the sixteenth century. 1013 CE), known in the West as Abulcasis. The earliest appreciation of syndactyly as a birth anomaly or burn-trauma can be traced back to the Andalusian Muslim surgeon Al-Zahrawi (d. This is most commonly seen in complex syndactyly (when there has been a bone joining of the fingers). Finally, the fingers may deviate after surgery. Also, if the skin grafts are harvested from the groin area, the skin may grow hair. One critique of using skin grafts is that the grafts darken in the years after surgery and become more noticeable. Additional surgery may be required to correct this. This is likely due to tension at the site of the repair between the digits. The most common problem with syndactyly correction is creeping of the skin towards the fingertip over time. Skin can also be used from the back of the hand by mobilizing it (called a "graftless" syndactyly correction), which requires planning over a period of months prior to surgery. This is most commonly done with a skin graft (from groin or anterior elbow). Therefore, the surgeon must bring new skin into the area at the time of surgery. The treatment of syndactyly of the other digits is elective and is more commonly performed when the digits have grown, at 18–24 months of age.īecause the circumference of the conjoined fingers is smaller than the circumference of the two separated fingers, there is not enough skin to cover both digits once they are separated at the time of surgery. Typically, syndactyly of these digits is treated at six months of age. Syndactyly of the border digits (thumb/index finger or ring/small fingers) is treated at early age to prevent the larger digit from curving towards the smaller digit with growth. ( February 2020) ( Learn how and when to remove this template message) Unsourced material may be challenged and removed. Please help improve this section by adding citations to reliable sources. type V: 2q31-q32 similar to type I, but the metacarpals and metatarsals may also be fused. ![]() type IV: 7q36 involves all fingers and/or toes.type III: 6q21-q23 small finger is merged into the ring finger.type II: 2q31 also involves long and ring fingers, but has a sixth finger merged in between.type I: 2q34-q36 webbing occurs between middle and ring fingers and/or second and third toes.The corresponding loci associated with these types and their common phenotypical expression are as follows: Genetics įive types of syndactyly have been identified in humans. In some fetuses, this process does not occur completely between all fingers or toes and some residual webbing remains. At about 6 weeks of gestation, apoptosis takes place due to a protein named sonic hedgehog, also known as SHH, which dissolves the tissue between the fingers and toes, and the webbing disappears. In early human fetal development, webbing (syndactyly) of the toes and fingers is normal. Simple syndactyly can be full or partial, and is present at birth (congenital). This type of syndactyly is found in amniotic band syndrome. In incomplete syndactyly, the skin is only joined part of the distance to the tip of the involved digits.Ĭomplex syndactyly occurs as part of a syndrome (such as Apert syndrome) and typically involves more digits than simple syndactyly.įenestrated syndactyly, also known as acrosyndactyly or terminal syndactyly, means the skin is joined for most of the digit but in a proximal area there are gaps in the syndactyly with normal skin.In complete syndactyly, the skin is joined all the way to the tip of the involved digits.Syndactyly can be complete or incomplete. The kangaroo exhibits complex syndactyly. In complex syndactyly, the bones of adjacent digits are fused.In simple syndactyly, adjacent fingers or toes are joined by soft tissue.The hand of a person with Greig cephalopolysyndactyly with syndactyly of several digits ![]() |
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